In site source and/or the options in Galleries / Other options / Lightbox Effects can not be saved.
As written in this topic.
Even tried the next link with instructions video, but still the SAVE button does not save the settings.
http://www.nextgen-gallery.com/nextgen- ... n-plugins/
Fixed this issue (but lost all pages / posts / comments / galleries):
http://wordpress.org/support/topic/next ... -address-2
DG.